- CD4 cells are a subset of T lymphocytes (helper T cells), which are part of the body’s defense against fungal, viral, and parasitic infections and exhibit some control over neoplastic growth.
- The normal CD4 cell count range is approximately 500 – 1500 cells/mm³.
- A drop in CD4 cell count indicates immune system deterioration.
- A CD4 cell count below 200 cells/mm³ is considered severe immune suppression.
- When the CD4 cell count drops below 200 cells/mm³, a patient will start to receive prophylaxis against certain opportunistic infections, such as Pneumocystis jerovecil pneumonia, formerly called Pneumocystis carinii pneumonia (PCP).
- A CD4 cell count below 200 cells/mm³ is a definition of AIDS.
- The development of oral lesions is associated with a decreased CD4 cell count.
HIV infection stage, based on age-specific CD+ T-lymphocyte count or CD4+ T-lymphopcyte percentage of total lymphocyte count
|Age on date of CD4 T-lymphocyte test|
| <1 year||1-5 years||6 years through adult|
|3|| <750|| <26|| <500|| <22|| <200|| <14||The stage is based primarily on the CD4+ T-lymphocyte count; the CD4+ T-lymphocyte count takes precedence over the CD4 T-lymphocyte percentage, and the percentage is considered only if the count is missing.|
- Medical Disorders
- Oral Health Care Considerations
- Laboratory Values
- Classifications and Definitions